Rosiglitazone helps to treat Diabetes in a number of ways. First of all, it works to lower the resistance to insulin in muscle, liver, and fat cells. It does this by going through a number of steps that are shown below.

1. The first action in the process to resensitize the cells that happens is that the rosiglitazone first attaches to the PPaRy receptor. The PPaRy receptor then is triggered by this to find and attach itself to another receptor, the PRXR strand, and bond with it.

2. When the PRXR and the PPaRy receptors are bonded, this triggers yet more chemicals to come and bond with the two receptors to start to form a makeshift 'factory' which will begin to produce the proteins that will resensitize the cell.

3. When the protein is finally created, it sends an RNA messenger out along the DNA.

Above is a more detailed picture of what the PPaRy and PRXR receptors look like when they are bound together. The PPaRy strand is on the left, with Rosiglitazone attached. On the right is the PRXR strand, with a ligand attached.

This image shows how the effects of Rosiglitazone differ in the three different target areas. In muscle cells for example, Rosiglitazone causes more glucose to be burnt up. In fatty cells, Rosiglitazone causes there more glucose to be stored in the cells.