Structure

Midazolam hydrochloride is a benzodiazepine which is usually administered intravenously for sedation. The chemical name is 8- chloro- 6- (2- fluorophenyl)-1 methyl- 4H- imidizo [1,5- a] [1,4] benzodiazepine hydrochloride; the empirical formula is C₁₈H₁₄Cl₂FN₃-HCl; the molecular weight is 362.25. At a pH of 5 or less, benzodiazepine ring is open and the molecule is water-soluble. On reaching pH 7.4 (in human blood), the ring closes and it becomes fat soluble.